Ecaterina Scarlatescu

Ecaterina Scarlatescu, MD, PhD (Katy) graduated from the University of Medicine and Pharmacy Carol Davila of Bucharest in 2005 and trained in Anaesthesia and Intensive Care medicine at Fundeni Clinical Institute, Bucharest, Romania. After the residency, she continued to work in the Department of Anaesthesiology and Intensive Care III at Fundeni Clinical Institute where she is appointed as Consultant. She is involved in clinical work (visceral and thoracic surgery, liver transplantation, care of the medical and surgical intensive care patients- both adults and pediatric patients), but also in research and training activities. She received a RTW Fellowship from the International Society on Hemostasis and Thrombosis in 2017, and trained for three months at Maastricht

University Medical Center in Maastricht, the Netherlands on the topics of the anticoagulant management in patients on extracorporeal life support and the use of thrombin generation tests. In 2018 she completed her PhD with the thesis “The complex assessment of coagulation disturbances in early sepsis and their prognostic significance”. Starting in 2018, she was appointed as a Co-Chair in the DIC Subcommittee of the International Society on Hemostasis and Thrombosis (ISTH).

Major research interests and current research projects include: the study of sepsis associated coagulopathy and sepsis induced DIC, the assessment of hemostasis in acute liver failure and end stage liver diseases, the assessment of coagulopathy in cirrhotic patients with sepsis and septic shock, bleeding management in liver transplantation, antithrombotic therapy monitoring in liver cirrhosis patients, extracorporeal blood purification therapies for supportive treatment of acute liver failure patients and as bridging to liver transplantation, the diagnostic and clinical implications of cirrhotic cardiomyopathy and postreperfusion syndrome during liver transplantation.

Ecaterina Scarlatescu's recent research

1. Scarlatescu E, Marchenko SP, Tomescu DR. Lidocaine effects on coagulation assessed by whole blood rotational thromboelastometry. Blood Coagul Fibrinolysis. 2021 Mar 1;32(2):115-121. PMID: 33443924 https://doi.org/10.1097/MBC.0000000000001002

2. Scarlatescu E, Marchenko SP, Tomescu DR. Cirrhotic Cardiomyopathy – A Veiled Threat. Cardiol Rev. 2020 Nov 20. PMID: 33229904 Epub ahead of print. https://doi.org/10.1097/CRD.0000000000000377

3. Scarlatescu E, White NJ, Tomescu DR. Standard and derived rotational thromboelastometry parameters for prediction of disseminated intravascular coagulation in septic patients. Blood Coagul Fibrinolysis. 2020 Jul;31(5):317-323. PMID: 32398464 https://doi.org/10.1097/MBC.0000000000000919

4. Scarlatescu E, Juffermans NP, Thachil J. The current status of viscoelastic testing in septic coagulopathy. Thromb Res. 2019 Nov;183:146-152. Epub 2019 Oct 23. PMID: 31678709. https://doi.org/10.1016/j.thromres.2019.09.029

5. Scărlătescu E, Lancé MD, White NJ, Tomescu DR. Thromboelastometric prediction of mortality using the kinetics of clot growth in critically ill septic patients. Blood Coagul Fibrinolysis. 2018 Sep; 29(6):533-539. PMID: 29985193. https://doi.org/10.1097/MBC.0000000000000757

6. Scărlătescu E, Tomescu DR. Prothrombotic State in a Patient With Acute Liver Failure: The Question of Anticoagulation. Semin Cardiothorac Vasc Anesth. 2018 Jun;22(2):174-179. Epub 2017 Nov 30. PMID: 29188763. https://doi.org/10.1177/1089253217745362

7. Scărlătescu E, Lancé MD, White NJ, Aramă SS, Tomescu DR. Effects of malignancy on blood coagulation in septic intensive care patients. Blood Coagul Fibrinolysis. 2018 Jan;29(1):92-96. PMID: 29095763 https://doi.org/10.1097/MBC.0000000000000680

8. Scarlatescu E, Tomescu D, Arama SS. Anticoagulant Therapy in Sepsis. The Importance of Timing. J Crit Care Med (Targu Mures). 2017 May 11;3(2):63-69. PMID: 29967873; PMCID: PMC5769917 https://doi.org/10.1515/jccm-2017-0011

9. Tomescu DR, Scarlatescu E, Bubenek-Turconi ŞI. Can goal-directed fluid therapy decrease the use of blood and hemoderivates in surgical patients? Minerva Anestesiol. 2020 Dec;86(12):1346-1352. . Epub 2020 Apr 6. PMID: 32251569. https://doi.org/10.23736/S0375-9393.20.14154-3

10. Marchenko SP, Scarlatescu E, Vogt PR, Naumov A, Bognenko S. Intermittent High-Frequency Percussive Ventilation Therapy in 3 Patients with Severe COVID-19 Pneumonia. Am J Case Rep. 2021 Feb 5;22:e928421. PMID: 33542171; PMCID: PMC7872946. https://doi.org/10.12659/AJCR.928421

11. Moore HB, Gando S, Iba T, Kim PY, Yeh CH, Brohi K, Hunt BJ, Levy JH, Draxler DF, Stanworth S, Görlinger K, Neal MD, Schreiber MA, Barrett CD, Medcalf RL, Moore EE, Mutch NJ, Thachil J, Urano T, Thomas S, Scărlătescu E, Walsh M; Subcommittees on Fibrinolysis, Disseminated Intravascular Coagulation, and Perioperative and Critical Care Thrombosis and Hemostasis. Defining trauma-induced coagulopathy with respect to future implications for patient management: Communication from the SSC of the ISTH. J Thromb Haemost. 2020 Mar;18(3):740-747. PMID: 32112533 https://doi.org/10.1111/jth.14690

12. Hartmann J, Walsh M, Grisoli A, Thomas AV, Shariff F, McCauley R, Vande Lune S, Zackariya N, Patel S, Farrell MS, Sixta S, March R, Evans E, Tracy R, Campello E, Scărlătescu E, Agostini V, Dias J, Greve S, Thomas S. Diagnosis and Treatment of Trauma-Induced Coagulopathy by Viscoelastography. Semin Thromb Hemost. 2020 Mar;46(2):134-146. . Epub 2020 Mar 11. PMID: 32160640 https://doi.org/10.1055/s-0040-1702171

13. Speybroeck J, Marsee M, Shariff F, Zackariya N, Grisoli A, Lune SV, Larson EE, Hatch J, McCauley R, Shariff F, Aversa JG, Son M, Agostini V, Campello E, Simioni P, Scărlătescu E, Kwaan H, Hartmann J, Fries D, Walsh M. Viscoelastic testing in benign hematologic disorders: Clinical perspectives and future implications of point-of-care testing to assess hemostatic competence. Transfusion. 2020 Oct;60 Suppl 6:S101-S121. PMID: 33089936 https://doi.org/10.1111/trf.16088

14. Walsh M, Kwaan H, McCauley R, Marsee M, Speybroeck J, Thomas S, Hatch J, Vande Lune S, Grisoli A, Wadsworth S, Shariff F, Aversa JG, Shariff F, Zackariya N, Khan R, Agostini V, Campello E, Simioni P, Scărlătescu E, Hartmann J. Viscoelastic testing in oncology patients (including for the diagnosis of fibrinolysis): Review of existing evidence, technology comparison, and clinical utility. Transfusion. 2020 Oct;60 Suppl 6:S86-S100. PMID: 33089937 https://doi.org/10.1111/trf.16102